Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

One-step base editing in multiple genes by direct embryo injection for pig trait improvement.

Science China. Life sciences - 1 Apr 2022

Song Ruigao, Wang Yu, Zheng Qiantao, Yao Jing, Cao Chunwei, Wang Yanfang, Zhao Jianguo

Abstract excerpt

The precise and simultaneous acquisition of multiple beneficial alleles in the genome is in great demand for the development of elite pig breeders. Cytidine base editors (CBEs) that convert C:G to T:A have emerged as powerful tools for single-nucleotide replacement. Whether CBEs can effectively mediate C-to-T substitution at multiple sites/loci for trait improvement by direct zygote injection has not been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Cas Systems

Share to Embryo, Mammalian

Share to Gene Editing

Source

Identifiers

PMID: 35060075
DOI: 10.1007/s11427-021-2013-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

One-step base editing in multiple genes by direct embryo injection for pig trait improvement.PMID 35060075Read ↗

Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skipping.Semantic proximity Read ↗

Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12iMax.Semantic proximity Read ↗

Adenine Base-Editing-Mediated Exon Skipping Induces Gene Knockout in Cultured Pig CellsSemantic proximity Read ↗

Application of the Modified Cytosine Base-Editing in the Cultured Cells of Bama MinipigSemantic proximity Read ↗

Effective generation of maternal genome point mutated porcine embryos by injection of cytosine base editor into germinal vesicle oocytes.Semantic proximity Read ↗

Base pair editing of goat embryos: nonsense codon introgression into <i>FGF5</i> to improve cashmere yieldSemantic proximity Read ↗

Optimization of the base editor BE4max in chicken somatic cells.Semantic proximity Read ↗

Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA.Semantic proximity Read ↗

Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos.Semantic proximity Read ↗

Generation of sheep with defined FecBB and TBXT mutations and porcine blastocysts with KCNJ5G151R/+ mutation using prime editing.Semantic proximity Read ↗

Genetically modified pigs for biomedical researchSemantic proximity Read ↗

Genome-wide Genetic Mutations Accumulated in Pigs Genome-edited for Xenotransplantation and Their Filial Generation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.