Article

Generation of GJB2 Gene-Edited Porcine Embryos as a Model for Human Congenital Deafness via CRISPR/Cas9 and Cytosine base editors

2025-11-14

Abstract excerpt

<title>Abstract</title> <p> Mutations in the <italic>GJB2</italic> gene, which encodes Connexin 26 (Cx26), are responsible for the majority of cases of non-syndromic congenital hearing loss in humans. While murine <italic>GJB2</italic> knockout models have provided mechanistic insight, anatomical and physiological differences limit their translational relevance. Pigs represent a valuable large-animal model b...

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Literature Corpus work: f6a87673-8d5d-5de4-9f98-e5c91abeec7c
DOI: 10.21203/rs.3.rs-7999953/v1

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