Article
A porcine congenital deafness model with unconditional knockout of GJB2 generated by CRISPR/Cas9 genomic editing.
Hearing research - 1 Mar 2026
Xie 谢飞 Fei, Liu 刘晓宙 Xiaozhou, Wang 王露露 Lulu, Zhang 张聪 Cong, Liu 刘传宏 Chuanhong, Huo 霍振庆 Zhenqing, Zhao 赵正东 Zhengdong, Zhao 赵清远 Qingyuan, He 贺秋月 Qiuyue, Guo 郭科男 Kenan, Sun 孙宇 Yu, Wang 王勇 Yong
Abstract excerpt
GJB2, the primary gene responsible for DFNB1, the most prevalent non-syndromic hearing loss (NSHL), has variants that account for over 50% of all prelingual hearing loss (HL). Mice are the main model for congenital hearing loss (CHL) research, but they have delayed auditory maturation postnatally, and unconditional Gjb2 knockout in mice causes embryonic lethality. Pigs have similar inner-ear anatomy to humans...
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