Article
Subclonal diversity arises early even in small colorectal tumours and contributes to differential growth fates.
Gut - 1 Dec 2017
Sievers Chelsie K, Zou Luli S, Pickhardt Perry J, Matkowskyj Kristina A, Albrecht Dawn M, Clipson Linda, Bacher Jeffery W, Pooler B Dustin, Moawad Fouad J, Cash Brooks D, Reichelderfer Mark, Vo Tien N, Newton Michael A, Larget Bret R, Halberg Richard B
Abstract excerpt
OBJECTIVE AND DESIGN: The goal of the study was to determine whether the mutational profile of early colorectal polyps correlated with growth behaviour. The growth of small polyps (6-9 mm) that were first identified during routine screening of patients was monitored over time by interval imaging with CT colonography. Mutations in these lesions with known growth rates were identified by targeted next-generation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.