Biomarkers of Leucine-Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy.

doi:10.1002/mds.70295

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Article

Biomarkers of Leucine-Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2026

Nielsen Louise-Kristine, Frost Joshua L I, Vaughan David P, Real Raquel, Fumi Riona, Jensen Marte Theilmann, Hodgson Megan, Stafford Eleanor J, Wu Lesley, Ansorge Olaf, Quaegebeur Annelies, Allinson Kieren S J, Warner Thomas T, Jaunmuktane Zane, Misbahuddin Anjum, Leigh P Nigel, Ghosh Boyd C P, Bhatia Kailash P, Church Alistair, Kobylecki Christopher, Hu Michele T M, Rowe James B, Shomo Alan A, Graham Danielle L, Mabrouk Omar S, Morris Huw R, Sammler Esther M, Jabbari Edwin

Abstract excerpt

BACKGROUND: Common and rare genetic variants in leucine-rich repeat kinase 2 (LRRK2) have been linked with sporadic and familial Parkinson's disease (PD). Recently, we discovered that common genetic variation near the LRRK2 locus determined survival in progressive supranuclear palsy (PSP). Our study aimed to explore biomarkers of LRRK2 and lysosomal dysfunction in PSP. METHODS: Immunoblotting was used to measure...

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PMID: 41987507
DOI: 10.1002/mds.70295
PMCID: PMC13387967

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