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Article

Profiling the Biochemical Signature of GBA-Related Parkinson's Disease in Peripheral Blood Mononuclear Cells.

Movement disorders : official journal of the Movement Disorder Society - 1 May 2021

Avenali Micol, Cerri Silvia, Ongari Gerardo, Ghezzi Cristina, Pacchetti Claudio, Tassorelli Cristina, Valente Enza Maria, Blandini Fabio

Abstract excerpt

BACKGROUND: GBA mutations are the commonest genetic risk factor for Parkinson's disease (PD) and also impact disease progression. OBJECTIVE: The objective of this study was to define a biochemical profile that could distinguish GBA-PD from non-mutated PD. METHODS: 29 GBA-PD, 37 non-mutated PD, and 40 controls were recruited; α-synuclein levels in plasma, exosomes, and peripheral blood mononuclear cells were...

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Identifiers

PMID: 33617695
DOI: 10.1002/mds.28496
PMCID: PMC8247888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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