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Article

LRRK2 Quantification in Cerebrospinal Fluid of Patients with Parkinson's Disease and Atypical Parkinsonian Syndromes.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2023

Mancini Andrea, Stoops Erik, Demeyer Leentje, Bellomo Giovanni, Paolini Paoletti Federico, Gaetani Lorenzo, Di Filippo Massimiliano, Parnetti Lucilla

Abstract excerpt

BACKGROUND: The alteration of leucine-rich repeat kinase 2 (LRRK2) kinase activity is thought to be involved in Parkinson's disease (PD) pathogenesis beyond familiar cases, and LRRK2 inhibitors are currently under investigation. Preliminary data suggest a relationship between LRRK2 alteration and cognitive impairment in PD. OBJECTIVE: To investigate cerebrospinal fluid (CSF) LRRK2 levels in PD and other...

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PMID: 36808643
DOI: 10.1002/mds.29336

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