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Article

Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2022

Wang Shijie, Unnithan Shakthi, Bryant Nicole, Chang Allison, Rosenthal Liana S, Pantelyat Alexander, Dawson Ted M, Al-Khalidi Hussein R, West Andrew B

Abstract excerpt

BACKGROUND: Pathogenic leucine-rich repeat kinase 2 LRRK2 mutations may increase LRRK2 kinase activity and Rab substrate phosphorylation. Genetic association studies link variation in LRRK2 to idiopathic Parkinson disease (iPD) risk. OBJECTIVES: Through measurements of the LRRK2 kinase substrate pT73-Rab10 in urinary extracellular vesicles, this study seeks to understand how LRRK2 kinase activity might change...

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Identifiers

PMID: 35521944
DOI: 10.1002/mds.29043
PMCID: PMC9308673

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