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Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation

2024-04-17

Abstract excerpt

<h4>Background</h4> LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson’s disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types of immunological responses. The identification of factors that regulate LRRK2-mediated Rab10 phosphorylation in iPD, and whether phosphorylated-Rab10 levels change in diffe...

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Literature Corpus work
c124422c-0d5f-5f83-963e-ab585afcac83
DOI
10.1101/2024.04.15.589570
Open publication

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Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammationDOI 10.1101/2024.04.15.589570
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