Article

Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable for Parkinson’s disease

2023-01-07

Abstract excerpt

Common and rare variants in the LRRK2 locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remains unknown. We performed comprehensive proteogenomic analyses using the largest aptamer-based CSF proteomics study to date (7,006 aptamers (6,138 unique proteins) in 3,107 individuals). We identified eleven independent SNPs in the LRRK2 locus associated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5480d62-f3cd-5707-81b3-9c4ee62bf49f
DOI: 10.1101/2023.01.05.23284241

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable for Parkinson’s diseaseDOI 10.1101/2023.01.05.23284241Read

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s diseaseSemantic proximity Read

A proteogenomic view of Parkinson’s disease causality and heterogeneitySemantic proximity Read

Parkinson’s disease causality and heterogeneity: a proteogenomic viewSemantic proximity Read

Parkinson’s disease causality and heterogeneity: a proteogenomic viewSemantic proximity Read

High-Throughput CSF Proteomics and Machine Learning to Identify Proteomic Signatures for Parkinson Disease Development and ProgressionSemantic proximity Read

Changes in the cerebrospinal fluid proteome precede and stratify the course of Parkinson’s DiseaseSemantic proximity Read

Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and cerebrospinal fluidSemantic proximity Read

Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson’s diseaseSemantic proximity Read

Identification of a novel proteomic Biomarker in Parkinson’s Disease: Discovery and Replication in Blood, brain and CSFSemantic proximity Read

Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls.Semantic proximity Read

Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson’s diseaseSemantic proximity Read

Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation.Semantic proximity Read