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Article

The Impact of 90 Parkinson's Disease-Risk Single Nucleotide Polymorphisms on Urinary Bis(monoacylglycerol)phosphate Levels in the Prodromal and PD Cohorts.

International journal of molecular sciences - 14 Feb 2024

Fang Shuai, Lee Priscilla Ann Hweek, Wang Zejian, Zhao Bo

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder with a prolonged prodromal phase. Higher urinary bis(monoacylglycerol)phosphate (BMP) levels associate with LRRK2 (leucine-rich repeat kinase 2) and GBA1 (glucocerebrosidase) mutations, and are considered as potential noninvasive biomarkers for predicting those mutations and PD progression. However, their reliability has been questioned, with...

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PMID: 38396963
DOI: 10.3390/ijms25042286
PMCID: PMC10889274

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