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Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

8 Jul 2023

Abstract excerpt

Common and rare variants in the LRRK2 locus are associated with Parkinson's disease (PD) risk, but the downstream effects of these variants on protein levels remain unknown. We performed comprehensive proteogenomic analyses using the largest aptamer-based CSF proteomics study to date (7006 aptamers (6138 unique proteins) in 3107 individuals). The dataset comprised six different and independent cohorts (five using...

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PMID: 37422510
DOI: 10.1038/s41531-023-00555-4

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