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Article

Biomarkers of LRRK2 and lysosomal dysfunction in Progressive Supranuclear Palsy

2025-12-01

Abstract excerpt

<h4>Background</h4> Common and rare genetic variants in LRRK2 have been linked with sporadic and familial Parkinson’s disease (PD). Recently, we discovered that common genetic variation near the LRRK2 locus determined survival in progressive supranuclear palsy (PSP). Our study aimed to explore biomarkers of LRRK2 and lysosomal dysfunction in PSP. <h4>Methods</h4> Immunoblotting was used to measure total LRRK2 an...

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Literature Corpus work
bad7c43c-f655-5ca8-b526-a245e4e6442b
DOI
10.1101/2025.11.24.25340830
Open publication

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Biomarkers of LRRK2 and lysosomal dysfunction in Progressive Supranuclear PalsyDOI 10.1101/2025.11.24.25340830
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