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Article

Tubulin acetylation deficiency promotes axonemal turnover and increases cytoplasmic microtubules.

Molecular biology of the cell - 1 Jun 2026

Kubo Tomohiro, Tajima-Shirasaki Natsumi, Sasaki Rinka, Oda Toshiyuki, Onishi Masayuki

Abstract excerpt

Tubulin post-translational modifications regulate microtubule dynamics. Although α-tubulin acetylation has been linked to microtubule stability, how this modification affects the overall organization of cellular microtubules remains obscure. Here, we generated a Chlamydomonas mutant lacking the acetyltransferase αTAT1, which completely abolished α-tubulin K40 acetylation. Surprisingly, the steady-state lengths of...

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Identifiers

PMID: 41985086
DOI: 10.1091/mbc.E26-01-0058
PMCID: PMC13200701

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