Article
αTAT1 is the major α-tubulin acetyltransferase in mice.
Nature communications - 1 Jan 2013
Kalebic Nereo, Sorrentino Simona, Perlas Emerald, Bolasco Giulia, Martinez Concepcion, Heppenstall Paul A
Abstract excerpt
Post-translational modification of tubulin serves as a powerful means for rapidly adjusting the functional diversity of microtubules. Acetylation of the ε-amino group of K40 in α-tubulin is one such modification that is highly conserved in ciliated organisms. Recently, αTAT1, a Gcn5-related N-acetyltransferase, was identified as an α-tubulin acetyltransferase in Tetrahymena and C. elegans. Here we generate mice...
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