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Article

Katanin regulates dynamics of microtubules and biogenesis of motile cilia.

The Journal of cell biology - 10 Sept 2007

Sharma Neeraj, Bryant Jessica, Wloga Dorota, Donaldson Rachel, Davis Richard C, Jerka-Dziadosz Maria, Gaertig Jacek

Abstract excerpt

The in vivo significance of microtubule severing and the mechanisms governing its spatial regulation are not well understood. In Tetrahymena, a cell type with elaborate microtubule arrays, we engineered null mutations in subunits of the microtubule-severing complex, katanin. We show that katanin activity is essential. The net effect of katanin on the polymer mass depends on the microtubule type and location....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17846175
DOI: 10.1083/jcb.200704021
PMCID: PMC2064628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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