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Article

⍺TAT1-dependent microtubule acetylation is required for touch sensation in zebrafish but not for cilia-driven morphogenesis.

Developmental biology - 1 Jul 2026

Bertrand Samuel G, Grimes Daniel T

Abstract excerpt

Acetylation of ⍺-tubulin at lysine 40 (⍺-tubK40Ac) is a conserved post-translational modification enriched on long-lived microtubules, yet its roles in vertebrate development remain incompletely defined. In zebrafish, morpholino-based knockdown of the ⍺-tubulin acetyltransferase ⍺TAT1 has been reported to cause severe developmental defects, in contrast to genetic studies in mammals. Here, we generated...

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Identifiers

PMID: 42034306
DOI: 10.1016/j.ydbio.2026.04.012

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