Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TP53 mutation landscape and patient survival in oral squamous cell carcinoma.

Japanese journal of clinical oncology - 6 Jul 2026

Ichikawa Mebae, Kondo Yusuke, Carreras Joaquim, Sasaki Masashi, Nagase Shunsuke, Hoshimoto Yasutaka, Tamura Masashi, Uchibori Masahiro, Aoki Takayuki, Nakamura Naoya, Masugi Yohei, Ota Yoshihide

Abstract excerpt

INTRODUCTION: TP53 mutations play a central role in the carcinogenesis of oral squamous cell carcinoma (OSCC). However, due to the diversity of variant patterns of TP53 genetic alterations, the clinical significance of TP53 mutations in OSCC remains poorly understood. Thus, we set out to analyze all exons of the TP53 gene to characterize the TP53 mutation landscape in OSCC and to investigate its associations with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Mouth Neoplasms

Share to Mutation

Share to Neoplasm Staging

Share to Prognosis

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 41980118
DOI: 10.1093/jjco/hyag056

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TP53 mutation landscape and patient survival in oral squamous cell carcinoma.PMID 41980118Read ↗

The mutational spectrum in whole exon of p53 in oral squamous cell carcinoma: Its clinical implicationsSemantic proximity Read ↗

The mutational spectrum in whole exon of p53 in oral squamous cell carcinoma and its clinical implications.Semantic proximity Read ↗

Functionally impactful TP53 mutations are associated with increased risk of extranodal extension in clinically advanced oral squamous cell carcinoma.Semantic proximity Read ↗

Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer.Semantic proximity Read ↗

Somatic mutations in oral squamous cell carcinomas in 98 Japanese patients and their clinical implications.Semantic proximity Read ↗

Ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identifies a mutation-based prognostic gene signature.Semantic proximity Read ↗

Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.Semantic proximity Read ↗

Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities.Semantic proximity Read ↗

Molecular characterisation in tongue squamous cell carcinoma reveals key variants potentially linked to clinical outcomes.Semantic proximity Read ↗

Relevance and actionable mutational spectrum in oral squamous cell carcinoma.Semantic proximity Read ↗

Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.Semantic proximity Read ↗

Targeted next-generation sequencing of TP53 in oral tongue carcinoma from non-smokers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.