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Article

Functionally impactful TP53 mutations are associated with increased risk of extranodal extension in clinically advanced oral squamous cell carcinoma.

Cancer - 15 Oct 2020

Gleber-Netto Frederico O, Neskey David, Costa Ana Flávia de Mattos, Kataria Pranav, Rao Xiayu, Wang Jing, Kowalski Luiz Paulo, Pickering Curtis R, Dias-Neto Emmanuel, Myers Jeffrey N

Abstract excerpt

BACKGROUND: The treatment of advanced oral squamous cell carcinoma (OSCC) is a clinical challenge because it is unclear which therapeutic approaches are the best for this highly heterogeneous group of patients. Because TP53 mutations are the most common genetic event in these tumors, the authors investigated whether they could represent an ancillary biomarker in the management of advanced OSCC. METHODS: The TP53...

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PMID: 32797678
DOI: 10.1002/cncr.33101

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