Article
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.
PloS one - 1 Jan 2013
Zanaruddin Sharifah Nurain Syed, Yee Pei San, Hor Seen Yii, Kong Yink Heay, Ghani Wan Maria Nabillah Wan Abd, Mustafa Wan Mahadzir Wan, Zain Rosnah Binti, Prime Stephen S, Rahman Zainal Ariff Abd, Cheong Sok-Ching
Abstract excerpt
OBJECTIVES: The frequency of common oncogenic mutations and TP53 was determined in Asian oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: The OncoCarta(™) panel v1.0 assay was used to characterize oncogenic mutations. In addition, exons 4-11 of the TP53 gene were sequenced. Statistical analyses were conducted to identify associations between mutations and selected clinico-pathological characteristics...
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