Article
Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.
Genome medicine - 23 Sept 2015
Vettore Andre Luiz, Ramnarayanan Kalpana, Poore Gregory, Lim Kevin, Ong Choon Kiat, Huang Kie Kyon, Leong Hui Sun, Chong Fui Teen, Lim Tony Kiat-Hon, Lim Weng Khong, Cutcutache Ioana, Mcpherson John R, Suzuki Yuka, Zhang Shenli, Skanthakumar Thakshayeni, Wang Weining, Tan Daniel S W, Cho Byoung Chul, Teh Bin Tean, Rozen Steve, Tan Patrick, Iyer N Gopalakrishna
Abstract excerpt
BACKGROUND: Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a change in the OTSCC epidemiological profile, with increasing incidence in younger patients, females and never-smokers. Here, we sought to characterize the OTSCC genomic landscape and to determine factors that may delineate...
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