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Article

Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer.

British journal of cancer - 1 Oct 2020

Caponio Vito Carlo Alberto, Troiano Giuseppe, Adipietro Iolanda, Zhurakivska Khrystyna, Arena Claudia, Mangieri Domenica, Mascitti Marco, Cirillo Nicola, Lo Muzio Lorenzo

Abstract excerpt

BACKGROUND: Mutations of the tumour-suppressor gene TP53 are the most frequent somatic genomic alterations in head and neck squamous cell carcinoma (HNSCC). However, it is not yet clear whether specific TP53 mutations bear distinct clinical and pathophysiological significance in different HNSCC subgroups. METHODS: A systematic bioinformatics appraisal of TP53 mutations was performed on 415 HNSCC cases available...

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Source

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Identifiers

PMID: 32684626
DOI: 10.1038/s41416-020-0984-6
PMCID: PMC7553957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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