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Article

Ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identifies a mutation-based prognostic gene signature.

Oncotarget - 20 Jul 2015

Chen Shu-Jen, Liu Hsuan, Liao Chun-Ta, Huang Po-Jung, Huang Yi, Hsu An, Tang Petrus, Chang Yu-Sun, Chen Hua-Chien, Yen Tzu-Chen

Abstract excerpt

BACKGROUND: Patients with advanced oral squamous cell carcinoma (OSCC) have heterogeneous outcomes that limit the implementation of tailored treatment options. Genetic markers for improved prognostic stratification are eagerly awaited. METHODS: Herein, next-generation sequencing (NGS) was perform...

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Topics

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Share to Carcinoma, Squamous Cell
Share to Disease-Free Survival
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proportional Hazards Models

Share to Squamous Cell Carcinoma of Head and Neck

Source

Open in PubMed Open full text

Identifiers

PMID: 25980437
DOI: 10.18632/oncotarget.3768
PMCID: PMC4621868

Genes

BRAF
HRAS
AKT1
CTNNB1
FGFR3
KIT
NOTCH1
PTEN
PTPN11
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25980437-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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