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Article

The mutational spectrum in whole exon of p53 in oral squamous cell carcinoma and its clinical implications.

Scientific reports - 15 Dec 2022

Hyodo Toshiki, Kuribayashi Nobuyuki, Fukumoto Chonji, Komiyama Yuske, Shiraishi Ryo, Kamimura Ryouta, Sawatani Yuta, Yaguchi Erika, Hasegawa Tomonori, Izumi Sayaka, Wakui Takahiro, Nakashiro Koh-Ichi, Uchida Daisuke, Kawamata Hitoshi

Abstract excerpt

Mutations in p53 are common in human oral squamous cell carcinoma (OSCC). However, in previous analyses, only detection of mutant p53 protein using immunohistochemistry or mutations in some exons have been examined. Full length mutant p53 protein in many cases shows a loss of tumor suppressor function, but in some cases possibly shows a gain of oncogenic function. In this study, we investigate relationships of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36522371
DOI: 10.1038/s41598-022-25744-8
PMCID: PMC9755123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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