Article
PHIP suppresses NuRD to enable the growth of SWI/SNF-mutant cancers.
Nature communications - 7 Apr 2026
Malone Hayden A, Myers Jacquelyn A, Gruss Emma G, Morgan Marc A, Friske Jake D, McCarty Tabitha C, Navarro John J, Robinson Sarah, Halliburton Rebecca L, Kietlinska Sandra J, De Luna Vitorino Francisca N, Hansen Baranda S, Pruett-Miller Shondra M, Garcia Benjamin A, Roussel Martine F, Partridge Janet F, Roberts Charles W M
Abstract excerpt
SWI/SNF chromatin remodeling complexes are perturbed in 20% of all cancers and in several developmental disorders, yet the mechanisms by which these mutations dysregulate transcription and drive disease are poorly understood. To both elucidate these mechanisms and identify vulnerabilities caused by these mutations, we leverage genome-wide CRISPR-Cas9 screening in hundreds of cancer cell lines and identify the...
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