Article
Vulnerabilities of mutant SWI/SNF complexes in cancer.
Cancer cell - 8 Sept 2014
Helming Katherine C, Wang Xiaofeng, Roberts Charles W M
Abstract excerpt
Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are particularly prevalent, occurring in 20% of all human cancers. As these are typically loss-of-function mutations and not directly therapeutically targetable, central goals have been...
Topics
- Animals
- Antineoplastic Agents
- Genetic Predisposition to Disease
- Humans
- Molecular Targeted Therapy
- Multiprotein Complexes
- Mutation
- Neoplasms
- Protein Subunits
- Transcription Factors