PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression.

doi:10.1038/s41467-024-51566-5

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Article

PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression.

Nature communications - 24 Aug 2024

Mittal Priya, Myers Jacquelyn A, Carter Raymond D, Radko-Juettner Sandi, Malone Hayden A, Rosikiewicz Wojciech, Robertson Alexis N, Zhu Zhexin, Narayanan Ishwarya V, Hansen Baranda S, Parrish Meadow, Bhanu Natarajan V, Mobley Robert J, Rehg Jerold E, Xu Beisi, Drosos Yiannis, Pruett-Miller Shondra M, Ljungman Mats, Garcia Benjamin A, Wu Gang, Partridge Janet F, Roberts Charles W M

Abstract excerpt

Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in nearly 25% of cancers. To gain insight into the mechanisms by which SWI/SNF mutations drive cancer, we contributed ten rhabdoid tumor (RT) cell lines mutant for SWI/SNF subunit SMARCB1 to a genome-scale CRISPR-Cas9 depletion screen performed across 896 cell lines. We identify PHF6 as specifically essential for RT cell survival...

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Identifiers

PMID: 39181868
DOI: 10.1038/s41467-024-51566-5
PMCID: PMC11344777

Genes

PHF6
SMARCB1

Provenance

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