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Article

FAM177A1 disrupts SIRT3-SOD2 signaling to drive mitochondrial dysfunction-mediated VSMC phenotypic switching in vascular remodeling.

International journal of biological sciences - 1 Jan 2026

Mao Ruiqi, Guo Yi, Jiang Ling, Bu Shichen, Chen Ming, Liang Minglu, Gao Xinyuan, Wu Yichen, Xu Wenjing, Chen Zilong, Huang Kai, Li Xiaoguang, Wang Cheng

Abstract excerpt

Aims: Vascular remodeling involves structural and functional vascular changes in response to injury, aging, and disease. A key pathological feature is vascular smooth muscle cells (VSMCs) phenotypic switching, which is accompanied by mitochondrial dysregulation. Metabolic reprogramming resembling the Warburg effect alongside mitochondrial oxidative damage collectively drive this pathological VSMC...

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Topics

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Share to Mitochondria
Share to Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Smooth Muscle

Share to Oxidative Phosphorylation

Share to Rats, Sprague-Dawley

Share to Sirtuin 3

Share to Superoxide Dismutase

Share to Vascular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 41943851
DOI: 10.7150/ijbs.128409
PMCID: PMC13050452

Genes

FAM177A1
SOD2
SIRT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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