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Article

Integration of Vascular Smooth Muscle Cell Phenotypic Switching and Senescence.

Journal of cardiovascular pharmacology - 1 Nov 2025

Deng Shiqi, Yin Xinglei, Zhu Ruigong

Abstract excerpt

ABSTRACT: Cardiovascular diseases are life-threatening conditions with multifactorial causes. As the most abundant cells in the vascular wall, vascular smooth muscle cells (VSMCs) play a crucial role in regulating vascular tone. Under physiologic conditions, VSMCs predominantly demonstrate a contractile phenotype. However, this phenotype can be altered in response to microenvironmental stimuli, particularly...

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Cardiovascular Diseases
Cell Plasticity
Cell Proliferation
Cell Transdifferentiation
Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

Myocytes, Smooth Muscle

Vascular Calcification

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PMID: 40815481
DOI: 10.1097/FJC.0000000000001752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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