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Article

Unraveling key genes and mitochondrial-related mechanisms of atherosclerosis severity: explorations based on interpretable machine learning.

BMC cardiovascular disorders - 9 Feb 2026

Kong De Zhao, Zhang Xue Zhi, Zhou Yuan Yuan, Wang Qun, Pan Yi Hui, Lu Yi, Ye Hui, Hong Xiong Yi

Abstract excerpt

BACKGROUND: Dysfunctional mitochondria increase oxidative stress and inflammation, driving atherosclerosis. Understanding gene expression and regulatory mechanisms is crucial. OBJECTIVE: This study aims to identify key mitochondrial dysfunction-related genes (MitoDEGs) associated with atherosclerotic plaque severity, elucidate their molecular mechanisms and immune-regulatory roles in disease progression, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41663970
DOI: 10.1186/s12872-026-05533-1
PMCID: PMC12983607

Genes

BID
GZMB
PMAIP1
CASP1
HK3
RAC2
TCL1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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