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Article

An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis.

Cellular and molecular life sciences : CMLS - 22 Dec 2021

Zhang Feng, Guo Xiaoqing, Xia Yuanpeng, Mao Ling

Abstract excerpt

Vascular smooth muscle cells (VSMCs) are involved in phenotypic switching in atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and transdifferentiation into other cell types. VSMC phenotypic transitions have historically been considered bidirectional processes. Cells can adopt a physiological contraction phenotype or an alternative "synthetic" phenotype in response to injury....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34936041
DOI: 10.1007/s00018-021-04079-z
PMCID: PMC11072026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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