Article
Molecular variants, clonal evolution and clinical relevance in pediatric and adult T-cell lymphoblastic neoplasia.
Blood cancer journal - 2 Apr 2026
Sandmann Sarah, Te Vrugt Marcel, Randau Gerrit, Beder Thomas, Neumann Martin, Lange Toni, Alfert Amelie, Mueller Stephanie, Hotfilder Marc, Rossi Corinne, Eckert Cornelia, Moericke Anja, Horns Johanna Maria, Zimmermann Martin, Varghese Julian, Brüggemann Monika, Burkhardt Birgit
Abstract excerpt
T-cell lymphoblastic lymphoma (T-LBL) and T-cell acute lymphoblastic leukemia (T-ALL) originate from thymic T-cell precursors, with ongoing debate on whether they are variants of the same disease or distinct entities. For 211 patients, including pediatric and adult T-ALL and T-LBL cases, targeted next-generation sequencing and SNP-arrays were performed, and single-nucleotide variants, indels and copy-number...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.