Article
The genomic landscape of teenage and young adult T-cell acute lymphoblastic leukemia.
Cancer medicine - 1 Jul 2021
Mansur Marcela B, Furness Caroline L, Nakjang Sirintra, Enshaei Amir, Alpar Donat, Colman Sue M, Minto Lynne, Irving Julie, Poole Beth V, Noronha Elda P, Savola Suvi, Iqbal Sameena, Gribben John, Pombo-de-Oliveira Maria S, Ford Tony M, Greaves Mel F, van Delft Frederik W
Abstract excerpt
BACKGROUND: Treatment on risk adapted intensive pediatric protocols has improved outcome for teenagers and young adults (TYA) with T-cell acute lymphoblastic leukemia (T-ALL). Understanding the biology of disease in this age group and the genetic basis of relapse is a key goal as patients with relapsed/refractory disease have poor outcomes with conventional chemotherapy and novel molecular targets are required....
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