Article
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.
Nature genetics - 1 Aug 2017
Liu Yu, Easton John, Shao Ying, Maciaszek Jamie, Wang Zhaoming, Wilkinson Mark R, McCastlain Kelly, Edmonson Michael, Pounds Stanley B, Shi Lei, Zhou Xin, Ma Xiaotu, Sioson Edgar, Li Yongjin, Rusch Michael, Gupta Pankaj, Pei Deqing, Cheng Cheng, Smith Malcolm A, Auvil Jaime M Guidry, Gerhard Daniela S, Relling Mary V, Winick Naomi J, Carroll Andrew J, Heerema Nyla A, Raetz Elizabeth, Devidas Meenakshi, Willman Cheryl L, Harvey Richard C, Carroll William L, Dunsmore Kimberly P, Winter Stuart S, Wood Brent L, Sorrentino Brian P, Downing James R, Loh Mignon L, Hunger Stephen P, Zhang Jinghui, Mullighan Charles G
Abstract excerpt
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of large T-ALL cohorts has not been carried out. Using integrated genomic analysis of 264 T-ALL cases, we identified 106 putative driver genes, half of which had not...
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