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Article

Two Faces of NOTCH1 in Childhood Lymphoblastic T-Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations.

Pediatric blood & cancer - 1 Jul 2026

Heider Marie C, Alfert Amelie, Hotfilder Marc, Burkardt Birgit, Te Vrugt Marcel

Abstract excerpt

In pediatric patients, T-cell lymphoblastic lymphoma (T-LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T-cell acute lymphoblastic leukemia (T-ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within one spectrum. This review focuses on T-LBL, summarizing shared and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to F-Box-WD Repeat-Containing Protein 7

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Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 42099099
DOI: 10.1002/1545-5017.70380

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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