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Article

Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes.

Blood cancer journal - 9 Nov 2021

Studd James B, Cornish Alex J, Hoang Phuc H, Law Philip, Kinnersley Ben, Houlston Richard

Abstract excerpt

To obtain a comprehensive picture of composite genetic driver events and clonal dynamics in subtypes of paediatric acute lymphoblastic leukaemia (ALL) we analysed tumour-normal whole genome sequencing and expression data from 361 newly diagnosed patients. We report the identification of both structural drivers, as well as recurrent non-coding variation in promoters. Additionally we found the transcriptional...

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Identifiers

PMID: 34753926
DOI: 10.1038/s41408-021-00570-9
PMCID: PMC8578656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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