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Article

The Profile of Immunophenotype and Genotype Aberrations in Subsets of Pediatric T-Cell Acute Lymphoblastic Leukemia

30 Apr 2019

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous malignancy, which reflects distinctive stages of T-cell differentiation arrest. We have revisited a cohort of pediatric T-ALL in order to test if immunophenotypes associated with molecular alterations would predict the patient’s outcome. Genetic mutations, translocations and copy number alterations were identified through Sanger...

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PMID: 31338319
DOI: 10.3389/fonc.2019.00316

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