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Article

TONSOKU prevents the formation of large tandem duplications and restrains ATR-WEE1 checkpoint activation.

Nature communications - 27 Mar 2026

Thomson Geoffrey, Poulet Axel, Huang Yi-Chun, Liao Hong-Sheng, LeBlanc Chantal, Jacob Yannick

Abstract excerpt

Copy number variation (CNV) plays a fundamental role in modulating plant agronomic traits and tumorigenesis in animals. While frequently linked to replication stress, the mechanisms giving rise to CNVs are not fully elucidated. Here we characterize the mutational consequences associated with losing the conserved TONSOKU (TSK/TONSL) pathway (CAF-1-H3.1-TSK), which is required to resolve impaired DNA replication...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41896247
DOI: 10.1038/s41467-026-70906-1
PMCID: PMC13031928

Genes

ATR
WEE1
TONSL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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