Article
DNA polymerase ε harmonizes topological states and R-loops formation to maintain genome integrity in Arabidopsis.
Nature communications - 27 Nov 2023
Li Qin, Zhou Jincong, Li Shuai, Zhang Weifeng, Du Yingxue, Li Kuan, Wang Yingxiang, Sun Qianwen
Abstract excerpt
Genome topology is tied to R-loop formation and genome stability. However, the regulatory mechanism remains to be elucidated. By establishing a system to sense the connections between R-loops and genome topology states, we show that inhibiting DNA topoisomerase 1 (TOP1i) triggers the global increase of R-loops (called topoR-loops) and DNA damages, which are exacerbated in the DNA damage repair-compromised mutant...
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