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Article

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations.

Cancer cell - 13 Aug 2018

Menghi Francesca, Barthel Floris P, Yadav Vinod, Tang Ming, Ji Bo, Tang Zhonghui, Carter Gregory W, Ruan Yijun, Scully Ralph, Verhaak Roel G W, Jonkers Jos, Liu Edison T

Abstract excerpt

The tandem duplicator phenotype (TDP) is a genome-wide instability configuration primarily observed in breast, ovarian, and endometrial carcinomas. Here, we stratify TDP tumors by classifying their tandem duplications (TDs) into three span intervals, with modal values of 11 kb, 231 kb, and 1.7 Mb, respectively. TDPs with ∼11 kb TDs feature loss of TP53 and BRCA1. TDPs with ∼231 kb and ∼1.7 Mb TDs associate with...

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Source

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Identifiers

PMID: 30017478
DOI: 10.1016/j.ccell.2018.06.008
PMCID: PMC6481635

Genes

BRCA1
CCNE1
CDK12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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