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Article

A DNA break-5mC cycle activates transposable elements in Arabidopsis.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jul 2026

Liang Wenjie, Cao Haokai, Zou Chen, Tong Xindong, Ma Yongbo, Shen Yitong, Han Xue, Zhang Yilin, Zheng Binglian, Li Jinchao

Abstract excerpt

Plant genomic and epigenomic integrity are perpetually threatened by exogenous and endogenous DNA damage. However, the interplay between DNA damage, DNA methylation (5mC), and transposable element (TE) activity remains poorly understood. Here, we demonstrate that defective single-strand break (SSB) repair acts as a potent trigger for genome-wide TE derepression and extensive de novo DNA methylation in...

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Identifiers

PMID: 42424424
DOI: 10.1073/pnas.2529943123
PMCID: PMC13367827

Genes

SSB
ROS1
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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