Article
The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication.
Science (New York, N.Y.) - 18 Mar 2022
Davarinejad Hossein, Huang Yi-Chun, Mermaz Benoit, LeBlanc Chantal, Poulet Axel, Thomson Geoffrey, Joly Valentin, Muñoz Marcelo, Arvanitis-Vigneault Alexis, Valsakumar Devisree, Villarino Gonzalo, Ross Alex, Rotstein Benjamin H, Alarcon Emilio I, Brunzelle Joseph S, Voigt Philipp, Dong Jie, Couture Jean-François, Jacob Yannick
Abstract excerpt
The tail of replication-dependent histone H3.1 varies from that of replication-independent H3.3 at the amino acid located at position 31 in plants and animals, but no function has been assigned to this residue to demonstrate a unique and conserved role for H3.1 during replication. We found that TONSOKU (TSK/TONSL), which rescues broken replication forks, specifically interacts with H3.1 via recognition of alanine...
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