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Article

Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases.

Nature - 19 Aug 2010

Jacob Yannick, Stroud Hume, Leblanc Chantal, Feng Suhua, Zhuo Luting, Caro Elena, Hassel Christiane, Gutierrez Crisanto, Michaels Scott D, Jacobsen Steven E

Abstract excerpt

Multiple pathways prevent DNA replication from occurring more than once per cell cycle. These pathways block re-replication by strictly controlling the activity of pre-replication complexes, which assemble at specific sites in the genome called origins. Here we show that mutations in the homologous histone 3 lysine 27 (H3K27) monomethyltransferases, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, lead...

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Identifiers

PMID: 20631708
DOI: 10.1038/nature09290
PMCID: PMC2964344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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