Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Short-Chain Fatty Acids and Palmitate Induce Distinct Metabolic and Phenotypic Signatures in Normal and Ischemic Skeletal Muscle Microvascular Endothelial Cells.

Cells - 10 Mar 2026

Guilfoyle-Speese Andrew, Patel Kripa, Ghanwat Aishwarya H, Stepp David, Ganta Vijay

Abstract excerpt

Background: Palmitate, a long-chain fatty acid, is well known to be a significant risk factor for cardiovascular diseases. In our current study, we wanted to determine whether palmitate treatment further aggravates ischemic endothelial cell (EC) injury and can serve as an in vitro model that emulates diabetic peripheral artery disease (diabetic-PAD). Short-chain fatty acid (SCFA) treatment was used as an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelial Cells
Share to Fatty Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycolysis

Share to Ischemia

Share to Microvessels

Share to Muscle, Skeletal

Share to Neovascularization, Physiologic

Share to Palmitates

Source

Open in PubMed Open full text

Identifiers

PMID: 41892284
DOI: 10.3390/cells15060493
PMCID: PMC13025840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Short-Chain Fatty Acids and Palmitate Induce Distinct Metabolic and Phenotypic Signatures in Normal and Ischemic Skeletal Muscle Microvascular Endothelial Cells.PMID 41892284Read ↗

Metabolism of vascular smooth muscle cells in vascular diseases.Semantic proximity Read ↗

Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Krüppel-Like Factor 4 (AMPK/KLF4) Signaling.Semantic proximity Read ↗

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolismSemantic proximity Read ↗

Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells.Semantic proximity Read ↗

Increased glycolysis is an early outcome of palmitate-mediated lipotoxicitySemantic proximity Read ↗

Palmitic acid inhibits vascular smooth muscle cell switch to synthetic phenotype through upregulation of miR-22 expressionSemantic proximity Read ↗

Inhibition of vascular intimal hyperplasia by the myokine Musclin: the role of NPR3/raptor/mTORC1-mediated glycolysis and phenotypic switching of VSMCs.Semantic proximity Read ↗

Palmitate-Associated ET-1 and PAI-1 Transcriptional Responses Under High-Glucose Conditions in HUVECs: An Exploratory Glucolipotoxic Stress ModelSemantic proximity Read ↗

Glycolysis and de novo fatty acid synthesis cooperatively regulate pathological vascular smooth muscle cell phenotypic switching and neointimal hyperplasia.Semantic proximity Read ↗

Mitochondrial Dysfunction in Endothelial Cells Drives Greater Vascular Impairment in Females with Diabetes-Associated Peripheral Artery DiseaseSemantic proximity Read ↗

Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation.Semantic proximity Read ↗

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative RetinopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.