Article

Palmitate-Associated ET-1 and PAI-1 Transcriptional Responses Under High-Glucose Conditions in HUVECs: An Exploratory Glucolipotoxic Stress Model

2026-06-22

Abstract excerpt

<title>Abstract</title> <p>Background Hyperglycemia and elevated saturated free fatty acids are key metabolic stressors implicated in vascular injury. However, the early transcriptional responses of endothelial cells to combined glucose and lipid stress remain incompletely defined. This exploratory in vitro study investigated whether high-glucose conditioning modifies palmitate-associated oxidative and endotheli...

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Literature Corpus work: c9e11894-51eb-50bb-9948-e9ba7140f864
DOI: 10.21203/rs.3.rs-10002537/v1

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