Article
Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Krüppel-Like Factor 4 (AMPK/KLF4) Signaling.
Journal of the American Heart Association - 23 Nov 2016
Sunaga Hiroaki, Matsui Hiroki, Anjo Saki, Syamsunarno Mas Risky A A, Koitabashi Norimichi, Iso Tatsuya, Matsuzaka Takashi, Shimano Hitoshi, Yokoyama Tomoyuki, Kurabayashi Masahiko
Abstract excerpt
BACKGROUND: Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has been lacking. We investigated the role of elongation of long-chain fatty acid member 6 (Elovl6), a...
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