Article

Increased glycolysis is an early outcome of palmitate-mediated lipotoxicity

2020-06-10

Abstract excerpt

Palmitic acid is the most abundant saturated fatty acid in human serum. In cell culture systems, palmitate overload is considered a toxic stimulus, and promotes lipid accumulation, insulin resistance, endoplasmic reticulum stress, oxidative stress, as well as cell death. An increased supply of fatty acids has also been shown to change the predominant form of the mitochondrial network, although the metabolic effect...

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Literature Corpus work: 9764724f-2a31-544e-abc0-fd97612f09d7
DOI: 10.1101/2020.06.10.144808

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