Article

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy

2023-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Healthy blood vessels supply neurons to preserve metabolic function. In blinding ischemic proliferative retinopathies (PRs), pathological neovascular tufts often emerge in lieu of needed physiological neuroretina revascularization. We show that metabolic shifts in the neurovascular niche define this angiogenic dichotomy between healthy and diseased blood vessel growth. Fatty acid oxidation (FAO)...

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Literature Corpus work: 15fa1525-26a8-564e-8f7e-626dbde782c2
DOI: 10.1101/2023.11.13.566898

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