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Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016

Li Xinyuan, Fang Pu, Li Yafeng, Kuo Yin-Ming, Andrews Andrew J, Nanayakkara Gayani, Johnson Candice, Fu Hangfei, Shan Huimin, Du Fuyong, Hoffman Nicholas E, Yu Daohai, Eguchi Satoru, Madesh Muniswamy, Koch Walter J, Sun Jianxin, Jiang Xiaohua, Wang Hong, Yang Xiaofeng

Abstract excerpt

OBJECTIVE: Hyperlipidemia-induced endothelial cell (EC) activation is considered as an initial event responsible for monocyte recruitment in atherogenesis. However, it remains poorly defined what is the mechanism underlying hyperlipidemia-induced EC activation. Here, we tested a novel hypothesis that mitochondrial reactive oxygen species (mtROS) serve as signaling mediators for EC activation in early...

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Identifiers

PMID: 27127201
DOI: 10.1161/ATVBAHA.115.306964
PMCID: PMC4882253

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