Article

Mitochondrial Dysfunction in Endothelial Cells Drives Greater Vascular Impairment in Females with Diabetes-Associated Peripheral Artery Disease

2025-09-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Women with peripheral artery disease (PAD) experience poorer clinical outcomes than men, particularly in the setting of diabetes. However, the mechanistic basis for these sex- specific disparities remains unclear. <h4>Methods</h4> Here, we investigated endothelial cell (EC) function(s) in diabetes-associated PAD, with a focus on sex differences. Limb tissues from patients w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94c7cf78-db0f-542d-a724-fcaeb13f2698
DOI: 10.1101/2025.09.22.677648

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial Dysfunction in Endothelial Cells Drives Greater Vascular Impairment in Females with Diabetes-Associated Peripheral Artery DiseaseDOI 10.1101/2025.09.22.677648Read

Unraveling the Role of Sex in Endothelial Cell Dysfunction: Evidence From Lineage Tracing Mice and Cultured CellsSemantic proximity Read

New insights into vascular aging: Emerging role of mitochondria functionSemantic proximity Read

Mitochondrial dysfunction in chronic ischemia and peripheral vascular diseaseSemantic proximity Read

Mitochondria in vascular diseaseSemantic proximity Read

Deciphering the Role of Ferroptosis in the Pathogenesis of Peripheral Artery Disease MyopathySemantic proximity Read

Mitochondria in Vascular Health and DiseaseSemantic proximity Read

Exploring the Molecular Link Between Diabetes and Erectile Dysfunction Through Single-Cell Transcriptome AnalysisSemantic proximity Read

Generation and Validation of a Lower Limb Muscle Single-Cell RNA Sequencing Data Set Identifies Pathogenic Endothelial Metabolism in Peripheral Arterial DiseaseSemantic proximity Read

Loss of endothelial cell heterogeneity in arteries after obesogenic dietSemantic proximity Read

Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue.Semantic proximity Read

GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function.Semantic proximity Read

Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors?Semantic proximity Read